Andrew Vaughn hit a three-run homer for the Milwaukee Brewers, who had five pitchers team up to limit the host St. Louis Cardinals to just four hits in a 6-2 victory on Wednesday afternoon.

Vaughn, reinstated from the injured list Monday after breaking the hamate bone in his left hand on Opening Day, capped a four-run first with his first homer of the season, which he hit off Andre Pallante 403 feet to left-center field.

Pallante (3-3) got the first two Brewers batters out to start the game, but he allowed Brice Turang to reach on a single and hit William Contreras. Jake Bauers singled home Turang before he and Contreras scored on Vaughn's blast, which came on a full count.

Milwaukee scored all its runs with two outs. Joey Ortiz scored on a Pallante wild pitch in the fifth, and Jackson Chourio's ninth-inning double to right off Matt Svanson scored Sal Frelick.

The Brewers pounded out 11 hits to split the two-game series with the Cardinals. Bauers went 2-for-3 with a walk. Vaughn added a single as part of a 2-for-4 day, while Chourio and Frelick both enjoyed 2-for-5 games.

Brandon Sproat threw four shutout innings and allowed just a hit while striking out five. However, three walks and a hit batsman kept the 25-year-old right-hander, who entered Wednesday having allowed 20 earned runs in 26 2/3 innings, from being able to claim his first career major league victory.

Aaron Ashby (6-0) allowed just a walk in two innings of relief to get the victory. DL Hall pitched a perfect fifth inning with a strikeout for the Brewers.

Pallante went six innings, gave up eight hits and two walks and struck out three.

The Cardinals' only hit through seven innings was Ivan Herrera's first-inning double. Alec Burleson put the hosts on the board with an eighth-inning single off Trevor Megill that scored Victor Scott II to end the shutout.

Cardinals left fielder Nathan Church exited after three innings due to a left leg contusion he suffered when Sproat hit him in the second.