Spencer Arrighetti carried a no-hitter into the eighth inning and Isaac Paredes provided early offensive support with a solo home run as the Houston Astros claimed the opener of a three-game series against the visiting Texas Rangers with a 2-0 victory on Friday.

Arrighetti (5-1) was exceptional throughout and found an early rhythm.

After issuing a two-out walk to Brandon Nimmo in the first inning, Arrighetti retired 11 consecutive batters. After retiring Kyle Higashioka on a flyout to left in the eighth, Arrighetti surrendered a sharp single to left by Justin Foscue that ended his no-hit hopes and concluded his outing. Arrighetti threw 102 pitches, one shy of his career high, and allowed one hit and four walks with five strikeouts over 7 1/3 innings.

Rangers right-hander Jack Leiter (1-4) nearly matched zeroes with Arrighetti. Paredes' fourth homer was the lone blemish for Leiter, who surrendered one run on three hits across seven innings.

Reds 7, Guardians 6

Matt McClain homered and drove in three runs and visiting Cincinnati held on for a win over Cleveland.

J.J. Bleday was 3-for-5 with two runs scored and an RBI for the Reds, who won their second straight. Winner Andrew Abbott (3-2) allowed a run on four hits in five-plus innings. He extended his shutout streak to 21 2/3 innings.

Jose Ramirez was 3-for-4 and drove in a run for the Guardians, who had their three-game winning streak snapped. Loser Tanner Bibee (0-6) went 6 2/3 innings, giving up three runs on seven hits. Cleveland has lost nine of his 10 starts.

Phillies 11, Pirates 9 (10 innings)

Bryce Harper collected four hits, including the game-tying single in the ninth inning, and Brandon Marsh delivered the go-ahead RBI in the 10th as visiting Philadelphia rallied for a win over Pittsburgh.

Kyle Schwarber homered twice for Philadelphia, giving him a major-league-high 20 on the season, including nine in the past eight games. He drove in five runs to help the Phillies improve to 13-4 under interim manager Don Mattingly.

Brandon Lowe recorded his third multi-homer game of the season for Pittsburgh, which led 6-0 after the third inning and 8-5 in the ninth. Oneil Cruz and Marcell Ozuna each drove in a pair of runs for the Pirates.

Padres 2, Mariners 0

Randy Vasquez pitched six scoreless innings as San Diego clinched the Vedder Cup with a shutout victory against host Seattle.

The Padres improved to 4-0 in the six-game season series against the Mariners, with whom they share a spring training complex in Peoria, Ariz. The Vedder Cup is named for Pearl Jam frontman Eddie Vedder, who has ties to both San Diego and Seattle. Vasquez (5-1) allowed four hits.

Mariners right-hander Emerson Hancock (3-2) made a quality start. Hancock gave up one run on five hits over six innings.

Cubs 10, White Sox 5

Carson Kelly went 3-for-5 with four RBIs, including a go-ahead single in the seventh inning and two-run double in the eighth, to boost the visiting Cubs to a victory against the White Sox.

The Cubs stopped their crosstown rivals' five-game winning streak behind a 14-hit attack that included two-hit efforts from Alex Bregman, Ian Happ and Seiya Suzuki.

Cubs pitching overcame solo home runs from Colson Montgomery, Miguel Vargas and Jarred Kelenic. Drew Romo, Montgomery and Vargas had two hits each for the White Sox.

Cardinals 5, Royals 4 (11 innings)

Pinch hitter Yohel Pozo laced a walk-off RBI single with two outs in the 11th inning to propel St. Louis over visiting Kansas City.

After falling behind by one in the 10th, the Cardinals scored a run in each of the last two innings to secure their third win in four tries. Jordan Walker went 3-for-5 with a two-run home run.

In the top of the 10th, Bobby Witt Jr. double gave the Royals a 4-3 lead. Witt and Carter Jensen each had two hits and an RBI for Kansas City, which lost its fifth consecutive game.

Dodgers 6, Angels 0

Andy Pages and Max Muncy hit back-to-back home runs to highlight a four-run fourth inning and eight pitchers combined for a two-hitter as the Dodgers blanked the Angels in Anaheim, Calif.

Teoscar Hernandez also homered and had two hits for the Dodgers, who snapped a seven-game losing streak to their Southern California rivals. Edgardo Henriquez (2-0) tossed a hitless inning of relief for the Dodgers, who went with a bullpen game after Blake Snell landed on the injured list pregame.

Zach Neto singled and reached base four times for the Angels, who dropped their fourth straight. Jack Kochanowicz (2-3) allowed six runs on seven hits over six innings.

Nationals 3, Orioles 2

Daylen Lile finished a triple short of the cycle, Zack Littell (2-4) pitched five scoreless innings and Washington beat visiting Baltimore.

Lile has four homers in his past four games. The Nationals led 3-0 entering the ninth inning, when they needed three pitchers to get through the frame. Richard Lovelady retired just one of the three batters he faced but earned his second save.

Gunnar Henderson had two hits and an RBI for the Orioles. Shane Baz (1-5) threw seven innings, allowing three runs on six hits.

Tigers 3, Blue Jays 2

Spencer Torkelson's two-out RBI single brought home the winning run in the ninth inning as host Detroit edged Toronto.

Torkelson's opposite-field single off Jeff Hoffman (2-3) knocked in Matt Vierling, who reached on a bloop single and stole second. Detroit had lost eight of its last nine games, including three straight.

Riley Greene had an RBI double to extend his hitting streak to 10 games. Greene has the longest active hitting streak in the majors and has reached base safely in a career-high 25 consecutive games. Andres Gimenez drove in both Toronto runs with a double.

Braves 3, Red Sox 2 (10 innings)

Mike Yastrzemski's leadoff double in the bottom of the 10th inning propelled Atlanta over visiting Boston.

Drake Baldwin went 2-for-4 with a home run that gave the Braves a first-inning lead. Michael Harris II also went deep before the Red Sox clawed back into a tie game with single runs in both the sixth and seventh innings.

The last of five Atlanta relievers to appear, Didier Fuentes (3-0) stranded two runners on base to post a scoreless 10th. Marcelo Mayer hit a game-tying homer for Boston, which has lost four of its last five.

Brewers 3, Twins 2

Jake Bauers' RBI double and a controversial eighth-inning call helped Milwaukee edge Minnesota in Minneapolis.

Jackson Chourio had two hits and two runs and Bauers was 2-for-4. Reliever Aaron Ashby (8-0) allowed the tying run, yet was awarded the win as he gave up four hits and one run in two innings. Trevor Megill notched his fifth save with a 1-2-3 ninth.

Ryan Kreidler had two hits for the Twins. Joe Ryan yielded four hits, one run and fanned seven over six innings.

Yankees 5, Mets 2

Cam Schlittler continued his impressive start by allowing one run over 6 2/3 innings for the visiting Yankees, who beat the Mets in the first Subway Series game of the season.

Cody Bellinger and Jazz Chisholm Jr. had consecutive RBI doubles during a three-run third for the Yankees, who won for just the third time in nine games. Spencer Jones hit an RBI single in the fifth and Ben Rice homered in the ninth. Chisholm had three hits and a stolen base, while Rice also had three hits. Jones finished with two hits.

Juan Soto homered and Brett Baty had two hits, including an RBI single, for the Mets, who had their three-game winning streak snapped. Starter Clay Holmes (4-4) suffered a fractured right fibula, Mets manager Carlos Mendoza told reporters after the game.

Diamondbacks 9, Rockies 1

A six-run first inning set the table for Merrill Kelly's first career complete game as Arizona cruised to a win over Colorado in Denver.

Ildemaro Vargas was 4-for-5 with a double and two RBIs for Arizona. Kelly (3-3) needed just 100 pitches to record all 27 outs. He settled into the game after allowing a Hunter Goodman first-inning homer, yielding a total of four hits.

Colorado starter Kyle Freeland (1-5) gave up seven runs on eight hits in 3 2/3 innings. Hunter Goodman took Kelly deep in the first for the Rockies' lone run.

Athletics 5, Giants 2

Nick Kurtz drilled a go-ahead, three-run homer to extend his streak of reaching base to 38 games while leading the Athletics to a victory over San Francisco at West Sacramento, Calif.

Rookie Henry Bolte and veteran Jeff McNeil each had two hits and one RBI for the Athletics, who had lost three of their previous four games. Aaron Civale (5-1) allowed two runs and six hits over five innings to win his third consecutive start.

Luis Arraez had four hits, including his first homer of the season, for the Giants, who lost their third in a row. Harrison Bader also went deep and joined Willy Adames with two hits for San Francisco. Tyler Mahle (1-5) was roughed up for five runs and 10 hits over five innings.