Coby Mayo hit a three-run home run and the Baltimore Orioles, who didn't have a hit until the seventh inning, beat the visiting New York Yankees 3-2 in the opener of a three-game series on Monday night.

Mayo's homer came on the third pitch from reliever Brent Headrick after Ryan Weathers had silenced the Orioles for the first six-plus innings.

Baltimore, despite producing only three hits, won its second game in a row by notching just its fourth victory in a 12-game stretch. The Orioles began to make amends after they were four-game sweep victims of the Yankees earlier in the month in New York.

Ben Rice's two-run home run provided the Yankees' offense, but New York lost its fourth game in a row. Weathers entered the seventh with a no-hitter until Adley Rutschman's lead-off single. After a groundout and a walk to Tyler O'Neill, Weathers was replaced.

Diamondbacks 1, Rangers 0

Michael Soroka pitched 6 1/3 innings, Geraldo Perdomo doubled in the only run in the first inning, and Arizona got a shutout win in Arlington, Texas.

Soroka (5-2) gave up just three hits, all singles. Paul Sewald pitched the ninth inning for his ninth save. Perdomo and Nolan Arenado had two hits apiece for the Diamondbacks, who have won three in a row.

Jakob Junis (0-1) gave up the only run in the first inning while starting in place of Nathan Eovaldi, who was a late scratch due to left side tightness. The Rangers had a two-game winning streak end.

Giants 9, Dodgers 3

Rafael Devers had two hits, two RBIs and three runs, Heliot Ramos and Willy Adames delivered two-run hits and San Francisco spoiled Mookie Betts' return to the lineup with a win at Los Angeles.

Having missed five weeks with a strained right oblique, Betts went 1-for-5 with a strikeout as the Dodgers lost their third straight.

Giants reliever Matt Gage (3-1) retired all five batters he faced. Max Muncy homered and singled for the Dodgers. Alex Vesia (1-1) permitted three runs and got just one out.

Guardians 7, Angels 2

Daniel Schneemann, Travis Bazzana and Brayan Rocchio each drove in two runs as host Cleveland opened the three-game series by cruising past Los Angeles.

Guardians starter Joey Cantillo (3-1) tossed six shutout innings, scattering five hits. David Fry went 2-for-3 with a double, a run and an RBI and Kyle Manzardo finished 2-for-4 with a double and two runs for Cleveland, which drew 10 walks.

Nolan Schanuel and Jo Adell each had two hits for the Angels. Starting pitcher Brent Suter (1-2) gave up two runs on two hits in 1 2/3 innings.

Rays 8, Blue Jays 5

Jonathan Aranda had a solo homer and three RBIs and Tampa Bay defeated host Toronto to begin a three-game set.

Richie Palacios added three hits and three RBIs for Tampa Bay, which is 4-0 against Toronto. Drew Rasmussen (3-1) completed six innings, allowing three runs and four hits. Bryan Baker pitched a perfect bottom of the ninth to earn his 11th save.

Toronto's Andres Gimenez had a career-best five RBIs with two home runs. Kevin Gausman (2-3) recorded his 2,000th career strikeout but allowed seven runs (six earned) and 10 hits in 4 2/3 innings.

Mariners 3, Astros 1

George Kirby posted a season-high seven strikeouts while Julio Rodriguez homered as visiting Seattle claimed the opener of a four-game series against Houston.

Kirby (5-2) continued his stellar pitching against the Astros. He entered his 11th career regular-season start against Houston with a 5-1 record and 2.17 ERA, and while he logged a season-low five innings, Kirby maintained his previous standard of success.

Astros right-hander Peter Lambert (2-3) matched his career high of seven innings for a second consecutive start.