Mike Trout hit his 415th career homer, singled, walked twice and scored two runs to lead the Los Angeles Angels to a 4-3 victory over the Chicago White Sox on Tuesday night in Anaheim, Calif.

Zach Neto went 2-for-4 with a home run and Jorge Soler also hit a home run for Los Angeles, which snapped a two-game skid and won for just the second time in 11 games.

Jose Fermin (1-1) struck out two during a scoreless inning of relief and Ryan Zeferjahn pitched out of a bases-loaded jam in the ninth to pick up his first save.

Chase Meidroth homered and had two hits and two runs and Andrew Benintendi also had two hits for Chicago, which lost to the Angels for the first time in five games this season. Erick Fedde (0-4) allowed four runs on six hits over 4 2/3 innings. He walked two and struck out two.

Chicago, which pounded out 16 hits en route to a 6-0 victory in Monday's series opener, jumped out to a 2-0 lead in the first inning. Meidroth led off with a single and Miguel Vargas and Colson Montgomery followed with back-to-back walks against Angels starter Sam Aldegheri. Randal Grichuk then drove in Meidroth with a broken-bat single to right, and Edgar Quero followed with a sacrifice fly.

Los Angeles tied it in the bottom of the first on home runs by Trout, a 367-foot line drive into the front row in left, and Soler, a 410-foot drive to left-center. It was Trout's 11th home run of the season and broke a tie with Darrell Evans for 55th place on the all-time home run list.

Neto, who ended an 0-for-23 slump with a single in the third, then gave the Angels a 3-2 lead in the fifth with his sixth home run, a 410-foot drive to the back of the bullpen in left-center, his first homer since April 10. Trout followed with a walk and then scored the eventual game-winning run on a double into the right field corner by Nolan Schanuel.

The White Sox cut the lead to 4-3 in the seventh when Meidroth led off with his second home run, a 372-foot drive just inside the left field foul pole.