Miguel Vargas and Jacob Gonzalez each hit three-run homers in an epic, 10-run third inning, Chicago's best this season, and the White Sox demolished the visiting Kansas City Royals 22-1 on Friday night.

Tristan Peters popped a grand slam and posted six RBIs, and Kyle Teel (three RBIs) and Andrew Benintendi also went deep. Chase Meidroth had four hits, while Gonzalez and Vargas had three hits and five RBIs apiece. Sam Antonacci notched three hits as the team totaled 23.

Recalled earlier in the day from Triple-A Charlotte, White Sox starter David Sandlin (2-1) allowed one run on three hits in six innings. The rookie right-hander fanned six, walked three and induced two double plays.

The Royals' Carter Jensen singled for a 17-game hitting streak, and Jac Caglianone tripled and walked. Kansas City totaled four hits. Designated hitter Bobby Witt Jr. (knee sprain) returned after a six-game absence and went 0-for-3 with a run and a walk.

Brewers 6, Cubs 2

Garrett Mitchell and William Contreras had two-run homers and hard-throwing Jacob Misiorowski allowed one run over six innings to pace Milwaukee to a victory over visiting Chicago in the opener of the three-game National League Central showdown series.

Misiorowski (9-3) allowed two hits, including a solo homer by Seiya Suzuki, striking out eight and walking four. Misiorowski, who set a major league record for starters with a first-inning fastball clocked at 105.5 mph, boosted his major league-leading strikeout total to 146 and kept his majors-best ERA at 1.45.

For the Cubs, Suzuki drilled a homer and added a sacrifice fly. Starter Colin Rea allowed one run on five hits in five-plus innings and escaped several jams over five scoreless innings.

Red Sox 6, Yankees 1

Payton Tolle pitched seven dominant innings and combined with two relievers on a three-hitter as Boston earned a victory over visiting New York.

Tolle (4-5) retired the first 16 hitters before rookie Spencer Jones looped a single in the sixth. The left-hander struck out seven and permitted only three baserunners. Willson Contreras launched a two-run homer and Conor Wong contributed a pair of RBIs as Boston secured a series win.

New York's Will Warren (7-3) allowed five runs on seven hits in 5 2/3 innings. The right-hander threw 55 of 90 pitches for strikes, did not register a strikeout and issued three walks. He and Contreras jawed at each other after Contreras' homer, leading the benches and bullpens to clear with no further escalation.

Reds 6, Pirates 4

Noelvi Marte's first career pinch-hit home run in the eighth inning lifted Cincinnati to a road victory over Pittsburgh.

Marte's two-run homer off reliever Mason Montgomery (2-3) helped snap the Reds' three-game losing streak and was only the third win for Cincinnati against a NL Central opponent in 19 games this season. Marte's homer followed Sal Stewart's one-out single in the eighth, which snapped a streak of 13 consecutive Reds batters retired by Pirates pitchers.

Pittsburgh lost for the eighth consecutive time when ace and reigning NL Cy Young winner Paul Skenes pitches.

Tigers 8, Astros 0

James Outman hit a three-run homer to support seven strong innings from Keider Montero as host Detroit blanked Houston.

Kerry Carpenter supplied a two-run homer, his 11th of the season, while Colt Keith contributed a solo blast. Kevin McGonigle reached base three times, stole two bases and scored two runs. The Tigers snapped a three-game losing streak.

The Astros saw their three-game winning streak come to an end. Starter Spencer Arrighetti gave up eight runs and five hits in three-plus innings. Jose Altuve was the only Houston player with multiple hits and the Astros were 0-for-5 with runners in scoring position and stranded six runners.

Orioles 3, Nationals 1

Trevor Rogers pitched into the seventh inning and Coby Mayo doubled twice and drove in a run as Baltimore returned home and produced a victory against Washington in the opener of a three-game series.

Blaze Alexander knocked in two runs and Taylor Ward provided three hits for the Orioles, who were home for the first time since going 4-5 on a nine-game West Coast trip. Rogers (5-7) won for the third time since April 1 by working 6 1/3 innings and holding the Nationals to one run on five hits and no walks.

Washington has lost four games in a row. No member of the team had more than one hit, though three of its five hits were doubles. The Nationals were held to one run for the third time this month. Starter Andrew Alvarez (1-1) was pulled after going 4 1/3 innings and charged with two runs on six hits.

Phillies 2, Mets 1

Zack Wheeler tossed seven strong innings for visiting Philadelphia, which edged struggling New York in the opener of a three-game series between the NL East rivals.

Trea Turner recorded the tie-breaking RBI single in the seventh inning for the Phillies, who have won four straight and six of seven. Bryce Harper had three singles, including a run-scoring hit in the first. Wheeler (8-1) allowed one run on four hits over seven innings.

Jared Young tied the score in the fourth with an RBI single for the Mets, who lost their seventh straight game hours after firing manager Carlos Mendoza and replacing him on an interim basis with Andy Green, the club's farm director. Rookie left-hander Zach Thornton settled down after a rocky first inning to toss six innings of one-run ball.

Rangers 5, Blue Jays 4

Nathan Eovaldi struck out nine in seven scoreless innings and visiting Texas held on to defeat Toronto.

Eovaldi (8-7) allowed five hits and one walk before leaving with a 5-0 lead. Justin Foscue hit a two-run home run and had three RBIs for the Rangers, who have two wins to open the four-game series. Wyatt Langford added three hits. Jacob Latz pitched around a walk in the ninth to earn his 16th save.

Kazuma Okamoto hit a two-run homer in a four-run eighth for the Blue Jays, who have lost four in a row. Former Ranger Patrick Corbin (2-4) allowed five runs and seven hits in 4 1/3 innings.

Mariners 3, Guardians 1

J.P. Crawford drove in the go-ahead run in the seventh inning with an infield single and Julio Rodriguez added an RBI hit in the eighth, giving visiting Seattle a victory over Cleveland.

Rookie Colt Emerson hit a solo homer in the third and Luis Castillo (3-6) worked six innings, giving up one run on four hits to earn his first win as a starter since May 14. Andres Munoz pitched a clean ninth for his 15th save in 20 opportunities. Seattle's pitchers retired the final 15 batters to wrap up the victory.

Rookie Kahlil Watson provided the Guardians' lone run in the first, doubling home Kyle Manzardo. Watson, batting cleanup, has seven RBIs in his last four games after starting his career 0-for-12. Tim Herrin (0-3) walked Cal Raleigh and Dominic Canzone upon entering the game, then gave up Crawford's two-out hit in his lone inning of relief.

Rays 6, Diamondbacks 1

Junior Caminero hit a three-run homer, Cedric Mullins added a solo shot and Nick Martinez pitched into the sixth inning to lead Tampa Bay to win over Arizona in St. Petersburg, Fla.

Martinez (7-2) allowed one run on six hits over 5 2/3 innings, and Yandy Diaz went 2-for-3 with a double, two runs and an RBI for the Rays.

Geraldo Perdomo homered, Corbin Carroll was 2-for-4 with a triple and Gabriel Moreno had two hits for Arizona. Zac Gallen (3-7) gave up five runs on four hits in 6 2/3 innings.

Marlins 4, Cardinals 0

Max Meyer allowed two hits in seven innings to win his ninth consecutive decision to start the season, Jakob Marsee singled in two runs and Miami shut out host St. Louis.

Meyer, who tied a Marlins record with his 9-0 start to a season, remains the only qualified starter in the major leagues without a loss this season. Michael Petersen and Calvin Faucher each pitched a scoreless inning to help Miami win its third straight game and improve to a major league-best 17-5 in June.

The Marlins broke a scoreless tie in the eighth against George Soriano (3-2) on Graham Pauley's RBI double. The Cardinals have lost three straight and six of their last eight. They received a strong outing from starter Michael McGreevy, who limited Miami to five hits over six scoreless innings.

Twins 9, Rockies 8 (10 innings)

Royce Lewis hit an RBI single in the 10th inning, and Minnesota recovered from losing a seven-run lead to beat Colorado in Minneapolis.

Lewis and Byron Buxton finished with three hits each, Kody Clemens and Brooks Lee homered and Trevor Larnach finished with two hits for the Twins.

Jake McCarthy homered and finished with three hits, Hunter Goodman also went deep and TJ Rumfield had two hits for the Rockies, who rallied again in the late innings but couldn't complete the comeback.

Athletics 9, Angels 3

Jeff McNeil and Henry Bolte each had two-run singles to highlight a seven-run fifth inning and help lead the Athletics to a victory over Los Angeles in the opener of a three-game series in Anaheim, Calif.

Nick Kurtz went 2-for-5 with two RBIs and two runs and Shea Langeliers had two hits, an RBI and a stolen base. Max Muncy also had two hits and a run for the Athletics, who won their second straight. J.T. Ginn (6-4) allowed three runs on eight hits over six innings.

Jo Adell homered and Denzer Guzman and Josh Lowe each had two hits for the Angels. Walbert Urena (5-6), who started the game by throwing four perfect innings, allowed seven runs on six hits over 4 1/3 innings.

Padres 7, Dodgers 1

Ty France belted a three-run homer and Walker Buehler pitched 5 1/3 solid innings in beating his former team for the first time as host San Diego stopped Los Angeles.

Right-hander Buehler (5-3) allowed three hits and a run, walking three and striking out five in a 74-pitch outing before letting relievers Yuki Matsui, Jason Adam, Adrian Morejon and Wandy Peralta pick up the last 11 outs.

Dodgers starter Roki Sasaki (3-5) lasted only four-plus innings, allowing three hits and three runs while walking five and striking out two. Los Angeles' only run came when Mookie Betts led off the second with his 10th homer.

Braves 3, Giants 1

Ozzie Albies drove in two runs, Reynaldo Lopez combined with five relievers on a seven-hitter and Atlanta opened a three-game road series with a win over San Francisco.

Making his first start since April 21, Lopez limited the Giants to one run and four hits before being pulled after three innings, having thrown 57 pitches. Braves reliever Dylan Lee (4-0), who threw 1 2/3 innings of one-hit ball, was credited with the win. Raisel Iglesias worked a 1-2-3 ninth for his 16th save.

All three Atlanta runs came against Giants starter Trevor McDonald (2-6), who allowed seven hits in 5 1/3 innings. San Francisco had four doubles but was out-hit 8-7 in losing for the fifth time in its last seven games.